Wap 57 sex
Transgenic mice were generated by microinjection into (C57BL/6 x C3H) F1 mouse embryos.This line has been backcrossed to C57BL/6 for more than 25 generations by the donating investigator."PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives.
Sequencing has identified the transgene integration site as intron 2 of the Pds5b gene (PDS5 cohesin associated factor B) on chromosome 5.
The 162 copy (approx 1.1 Mb) integration disrupts Pds5b rendering it a null allele.
Mice that are hemizygous for the transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
These transgenic mice express human ERBB2 (HER2) under the control of the mouse whey acid protein promoter (Wap).
As reported by Yong CSM et al (PLo S One 2015; 10(9):e0136817), the transgene inserted as a 162 bp concatemer (approx.
1.1 Mb) 19 nucleotides upstream of exon 3 of the Pds5b gene on Chr 5.
However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets.
Therefore, we cannot guarantee a strain's phenotype will meet all expectations.
The total number of animals provided, their gender and genotype will vary.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest.
If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks.