She appeared in the HBO television movie sequel If These Walls Could Talk 2 (2000).

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From then on, Williams began to work in independent features, which attracted smaller audiences.

"I feel like I haven't been working in a particularly flashy or visible way," she reflected to Vogue magazine.

She won a Golden Globe and an Independent Spirit Award for her portrayal of Marilyn Monroe in My Week with Marilyn (2011), which also garnered her BAFTA, SAG, and Academy Award nominations.

In 2016, she received wide acclaim for her performance in the drama Manchester by the Sea, earning her nominations from the BAFTA, SAG, and Academy Award ceremonies.

Williams and Chloƫ Sevigny appeared in the second segment, which revealed bitter divisions in the feminist movement during 1972.

While Entertainment Weekly critic, Ken Tucker, praised Sevigny, he said Williams had overdone her character's "grinning eagerness to be naughty".

you spend so much of the year doing something you are not entirely invested in.

So when you devote yourself to nine months of the year to that kind of work, you have to make awfully certain that you spend the three precious months off in a way that's true and not time-wasting.

As a child, Williams kept to herself and was self-sufficient; as she has said, "I was really secretive with my parents and I think I sort of continued that... I don't know why." Following this, Williams appearanced in the made-for-television movies My Son Is Innocent (1996), which saw her transition into more dramatic work, and Killing Mr.

Griffin (1997), where she plays a member of Susan's (played by Amy Jo Johnson) geek clique.

Wendy and Lucy, an acclaimed small-budget, low-key drama directed and co-written by Kelly Reichardt, follows Wendy, a drifter looking to start a new life, searching for her dog Lucy after a series of setbacks.