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Several cardiac defects have also been reported, including ventricular/atrial septal defects, atresia, hypoplastic right heart syndrome, patent ductus arteriosus, and conotruncal or valvular cardiac defects.

Tetrasomy X patients also appear to be more prone to seizure activity, although there is no documented abnormalities in brain function or structure when analyzed using an EEG or MRI.

A g TLD (generic top-level domain) for sexually explicit material was proposed as one tool for dealing with the conflict between those who wish to provide and access such material through the Internet, and those who wish to prevent access to it, either by children and adolescents, or by employees at their workplaces.

Advocates of the idea argue that it will be easier for parents and employers to block the entire TLD, rather than using more complex and error-prone content-based filtering, without imposing any restrictions on those who wish to access it.

Disorders of the eye include myopia, nystagmus, coloboma, microphthalmus, or optic nerve hypoplasia.

In terms of hearing, patients are more prone to ear infections, sound blockage, or nerve abnormalities.

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This can occur when homologous X chromosomes fail to separate in the formation of the egg or sperm.