Early in his career, he was best known for playing Dan Conner on the ABC TV series Roseanne (1988–1997), for which he won a Golden Globe Award for Best Actor in 1993.

He is also a regular collaborator with the Coen brothers on such films as Raising Arizona (1987), Barton Fink (1991), The Big Lebowski (1998), O Brother, Where Art Thou? Goodman's voice roles in animated films include Pacha in Disney's The Emperor's New Groove (2000), and Sulley in Pixar's Monsters, Inc. His other film performances include lead roles in The Babe (1992), The Flintstones (1994) and 10 Cloverfield Lane (2016) and supporting roles in Coyote Ugly (2000), The Artist (2011), Extremely Loud and Incredibly Close (2011), Argo (2012), Flight (2012), The Hangover Part III (2013), and Patriots Day (2016).

Brinkley divorced third husband Peter Cook in 2008, and is also mother to 20-year-old son Jack and 17-year-old daughter Sailor with the architect.

Lili and William Wilson are seeking an unspecified amount of compensation from International Polo Club Palm Beach founder John Goodman, 48 after he was accused of drunk driving in the February 2010 accident.

Actor John Goodman married Anna Beth Hartzog in October 1989.

By the year 1997 Goodman was having sex with someone other than his wife with every indication the illicit affair may have started some years earlier. Very few photos have been taken of the pair together and any that are in existance are mostly from their early days together.

In real life, the actress came out as lesbian in 2010.

"So there's something I've been wanting to talk to you about for a while now," she said as Darlene. I'm a talk show host." "Well, as long as you're happy, you know, me and your mom will support you," Goodman responded as Dan.

Joel is known for adding good-natured asides to the end of songs inspired by exes.

He and Brinkley were married from 1985 to 1994, and share 29-year-old daughter Alexa Ray Joel.

The 64-year-old actor and 42-year-old actress, who played dad and daughter Dan and Darlene Conner on the ABC sitcom, spoofed the series on Gilbert's talk show, .

Goodman and Gilbert staged a scene where Darlene "came out" to her father as a talk show host.

The 66-year-old singer was performing in Madison Square Garden when he referenced the 61-year-old model's new romance with Mellencamp.